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KMID : 0371620020170020123
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Journal of Wonkwang Medical Science
2002 Volume.17 No. 2 p.123 ~ p.132
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A study on the Expression of H-ras and c-myc in the Hepatocellular Carcinoma of the HBx Transgenic Mice
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Moon Hyung-Bae
So Byung-Jun
Kim Haak-Cheoul
Yun Ki-Jung
Han Won-Cheol
Jo Hyang-Jeong
Yu Dae-Yeul
Chung Yung-Jin
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Abstract
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Background: This experiment was designed for the expression of H-ras and c-myc in hepatocarcinogenesis of the HBx transgenic mice.
Methods: Immunohistochemical stains in the paraffin embedded tissue of the liver were used for the detection of H-ras and c-myc in the 12 normal mice and 44 HBx transgenic mice of the 4-18 month old.
Results: Expression of the H-ras was significantly increased in the dysplastic area (P<0.05) and tumor area (P<0.01) than in the normal liver. But there were no differences of H-ras expression between areas of microscopically identified hepatocellular carcinoma (MI-HCC) and grossly identified hepatocellular carcinoma (GI-HCC) and dysplastic areas among the only dysplastic areas, dysplastic areas with MI-HCC and GI-HCC. Expression of the c-myc was significantly increased in the tumor area (P<0.001) than in the normal liver and dysplastic area. But there were no differences of c-myc expression between areas of MI-HCC and GI-HCC, and dysplastic areas among only dysplastic areas, dysplastic areas with MI-HCC and GI-HCC.
Conclusions: Our study suggests that H-ras is related to the dysplastic change and c-myc is related to the neoplastic change in the hepatocarcinogenesis of the HBx transgenic mice.
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KEYWORD
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Tramsegenic, Hepatocellular, Carcinoma, H-ras, c-myc
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